Sr Scientist – Protein Engineering

Antibody Discovery And Protein Engineering        ·       South San Francisco, CA       ·       Full time

At Alector, our mission is to develop therapies that empower the immune system to combat neurodegeneration. Our team is solely focused on developing treatments for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and clinicians, leading healthcare investors, and pharma company partners who share in our commitment to bettering the lives of patients.

As a Senior Scientist for the antibody discovery and protein engineering (ADPE) group, you’ll work closely with scientists in both Research and Development to advance Alector programs forward. As a member of the protein engineering group you will help to design, generate and engineer therapeutic biologics with favorable functional and develop ability profiles.

Responsibilities:

• Contribute to the reagent designs for antibody discovery and engineering, and hypothesis-driven experimental designs to gain mechanistic insights
• Devise and execute antibody discovery campaign strategies including phage display and/or yeast display approaches to identify desirable antibodies against diverse targets
• Apply computational tools and antibody engineering expertise to design and execute humanization and affinity and developability optimization
• Serve as a program co-lead, coordinating antibody discovery and engineering data management, data analysis and presentations, in a collaborative and concise manner
• Perform library design, construction, selection and screening
• Lead target discovery and engineering workflows and contribute to key decisions on program progression with a fully integrated team
• Initiate and support implementations for antibody engineering technologies
• Help train and mentor junior scientists

During the first year, you will:

• Devise and execute library-based antibody discovery and engineering strategies to identify antibodies with desirable characteristics against diverse targets
• Serve as a program co-lead to collaborate with project teams by applying biotherapeutic cross-functional workflow and contributing to program progression decisions

We’d love to hear from you if:

• Your academic background includes a PhD with 4+years, MS with 7+ years, or BS with 10+ years of relevant hands-on experience (preferably in industry) in biochemistry, molecular biology, protein engineering or related field
• You have proven experience with antibody phage and/or yeast display
• You have a deep understanding of protein biochemistry, including binding characteristics, structure and function relationships
• You have strong expertise in a wide range of molecular biology and protein engineering techniques, including mutagenesis, molecular cloning, construct design, protein expression and purification, protein interaction characterization and DNA sequence analysis
• You are a diligent worker with strong skills in organization, data management, timeline management, and teamwork
• You have excellent interpersonal, communication and presentation skills with the ability to coach and mentor more junior scientists as well as positively influence project direction and strategy
• You take pride in being self-motivated and a creative problem solver
• You have a point of view but are low ego

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At Alector, we believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other’s assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.

Among the things you’ll discover at Alector on Day 1 and throughout your tenure: committed and driven colleagues, a bold and important company goal, brand-new brightly-lit offices in the heart of the biotech area, flexible remote work options, and competitive compensation and benefits. But these matters only if you’re excited to build and own something great, and tackle these challenges with us. Come join us!

Alector is a phenomenal place to learn and experiment. If you excel in a dynamic environment where everyone is committed to finding a treatment, where you’ll drive growth, this is your role. There is no limit to how far you can go with us.

Employees of Alector working on-site are required to be vaccinated against COVID-19, and are required to provide proof of vaccination. Employees may be entitled to an exception or reasonable accommodation if they cannot be vaccinated because of a disability/medical necessity, or sincerely held religious belief. 

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Please click here to apply.