Sr. Scientist, Protein Sciences Research

Antibody Discovery and Protein Engineering        ·       South San Francisco, CA       ·       Full time

At Alector, our mission is to develop therapies that empower the immune system to combat neurodegeneration. Our team is solely focused on developing treatments for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and clinicians, leading healthcare investors, and pharma company partners who share in our commitment to bettering the lives of patients.

As a Senior Scientist for the antibody discovery and protein engineering (ADPE) group, you’ll work closely with scientists in both Research and Development to advance Alector programs forward. As a member of the Protein Sciences group you will help to design and generate therapeutic reagents and biologics with favorable functional and developability profiles.

Responsibilities:

• Design constructs and implement expression/purification processes to generate protein reagents at milligram to gram level scales.
• Collaborate extensively across functions and contribute to prioritization and planning within group and project teams to meet company goals.
• Accurately and clearly document experimental notes, protocols, and results.
• Support development of novel technologies, including high throughput capabilities, for protein production, analytical, and characterizations.
• Prepare to learn and grow in a highly productive, fun and collaborative environment!

During the first year, you will:

• Support development of state-of-art Protein Sciences platform for protein production and analytics
• Lead efforts to develop protein production for novel antigens
• Serve as a functional representative to collaborate within ADPE, project teams and other cross-functional groups

We’d love to hear from you if:

• Your academic background includes a PhD in protein biochemistry with 3+ years therapeutic protein production experience, or MS with 7+ years, BS with 10+ years of therapeutic protein production experience.
• You have proven hands-on expertise in various protein characterization methods and tools including SDS-PAGE, WB, LAL, MCE, Analytical SEC and RP HPLC, MALS, DLS, DSF and mass spectrometryYou are an expert in protein purification using affinity, IEX, HIC and mixed-mode chromatography.
• You are capable of designing protein purification strategies and trouble-shooting problems independently.
• You have experience with generating high quality, difficult to-produce, low-expressing intracellular, membrane and/or secreted fusion proteins to enable antibody discovery and protein engineering.
• Your expertise in high throughput purification technologies would be a plus.
• You have excellent interpersonal, communication and presentation skills with the ability to mentor junior scientists as well as positively influence project direction and strategyYou take pride in being self-motivated and a creative problem solverYou have a point of view but are low ego

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At Alector, we believe that hard-working teams include people from a wide variety of backgrounds and experiences who can challenge each other’s assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, or disability status, or any other characteristics protected under applicable federal, state, or local laws.

Among the things you’ll discover at Alector on Day 1 and throughout your tenure: committed and driven colleagues, a bold and important company goal, brand-new brightly-lit offices in the heart of the biotech area, flexible remote work options, and competitive compensation and benefits. But these matters only if you’re excited to build and own something great, and tackle these challenges with us. Come join us!

Alector is a phenomenal place to learn and experiment. If you excel in a dynamic environment where everyone is committed to finding a treatment, where you’ll drive growth, this is your role. There is no limit to how far you can go with us.

Employees of Alector working on-site are required to be vaccinated against COVID-19, and are required to provide proof of vaccination. Employees may be entitled to an exception or reasonable accommodation if they cannot be vaccinated because of a disability/medical necessity, or sincerely held religious belief. 

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Please click here to apply.