Scientist – Mass Spectrometry & Infectious Disease

Platforms – Mass Spectrometry   ·      Stanford, California      ·       Full time

The Chan Zuckerberg Biohub (https://www.czbiohub.org) is a one-of-a-kind independent nonprofit research institute that brings together three powerhouse universities – Stanford, UC Berkeley, and UC San Francisco – into a single collaborative technology and discovery engine. CZ Biohub itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to make breakthroughs in medicine and develop new technologies, frequently in collaboration with our partner universities. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at CZ Biohub facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an inclusive organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

As part of a new intramural collaborative effort that spans our Quantitative Cell Science, Infectious Disease, and Technology Initiatives, we seek to comprehensively map how human cells get hijacked and remodeled during viral infection. In this context, we are investing resources and talent in cell biology, live-cell microscopy, biochemistry and genome engineering. One of our goals is to contribute open-source curated datasets that can be re-used by the entire community (see for example OpenCell).

This role will be a key collaborator embedded in our Intracellular Architecture and Mass Spectrometry Platform groups. This is a great opportunity to be part of a collegial multi-disciplinary team that combines genomics, high-throughput live cell imaging, mass-spec proteomics/metabolomics and robotics to decipher disease mechanisms.

We are seeking a Scientist to help establish an experimental and analytical proteomics pipeline to map how viruses remodel infected human cells and dissect associated molecular mechanisms (BSL-2 viral models). In collaboration with others at the Biohub,

You will  

• Fractionate, enrich, and isolate cell compartments relevant to infection progression
• Study protein networks using mass spectrometry-based proteomics
• Develop and optimize new mass spectrometry-based analytical techniques
• Analyze datasets
• Author publications
• Mentor junior colleagues

You have

Essential –

• Ph.D. in Cell Biology, Molecular Biology, Developmental Biology or a related field
• Proven track record in mass spectrometry-based analysis of large data set
• Demonstrable competency in mass spectrometer operation
• Strong knowledge of cell biology, cellular organelles, innate immune responses
• Broad understanding of modern analytical chemistry techniques
• Strong foundation in cell culture and molecular biology
• General enthusiasm for cellular mechanisms, systems biology, and open-source science
• Must be highly collaborative, team-oriented, and have excellent written and oral communication skills

 Nice to have –

• Direct experience with infection models
• Coding experience (Python, R, Matlab or similar languages)
• Previous experience with Bruker tims-TOF platform
• Prior analysis of Ion-Mobility mass spec data
• Experience integrating multi-omic datasets

Chan Zuckerberg Biohub requires all employees, contractors, and interns, regardless of work location or type of role, to provide proof of full COVID-19 vaccination, including a booster vaccine dose, if eligible, by their start date. Those who are unable to get vaccinated or obtain a booster dose because of a disability, or who choose not to be vaccinated due to a sincerely held religious belief, practice, or observance must have an approved exception prior to their start date.

What We Provide

• Resources to disrupt and innovate at the frontiers of our knowledge of biology and disease
• A collegial and collaborative environment consisting of diverse expertise
• Existing collaborations within CZ Biohub: Technology Platforms (Bioengineering, Computational Microscopy, Data Science, Genomic Sequencing, Mass Spectrometry/Proteomics), Infectious Disease, and Quantitative Cell Science
• Access to collaborators, resources and facilities at our three partner universities (Stanford, UC Berkeley, and UC San Francisco) and at partner organizations in the Bay Area and beyond
• Competitive compensation and benefits commensurate with the experience

Benefits

We offer a robust benefits program that enables the important work Biohubbers do everyday. Our benefits include healthcare coverage, life and disability insurance, commuter subsidies, family planning services with fertility care, childcare stipend, 401(k) match, flexible time off and a generous parental leave policy. In addition, we honor our commitment to career development and our value of scholarly excellence through regular onsite opportunities to learn from the world’s leading scientists.

CZ Biohub is an equal opportunity employer committed to diversity of thought, ideas and perspectives. We are committed to cultivating an inclusive organization where all Biohubbers feel inspired and know their work makes an important contribution. Therefore, we provide employment opportunities without regard to age, race, color, ancestry, national origin, religion, disability, sex, gender identity or expression, sexual orientation, or any other protected status in accordance with applicable law.

Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.

Headhunters and recruitment agencies may not submit resumes/CVs through this Web site or directly to managers. CZ Biohub does not accept unsolicited headhunter and agency resumes. CZ Biohub will not pay fees to any third-party agency or company that does not have a signed agreement with CZ Biohub.

Please click here to apply.