Senior / Principal Scientist Development

Research & Development     ·      San Francisco, California, United States of America     ·    Full time

Job Summary:

The successful candidate for Senior/Principal Scientist will provide scientific leadership and play an active role in the process of drug development from discovery through marketed products, with an emphasis on Genentech’s diverse OMNI (Ophthalmology, Metabolic disease, Neuro science & Immunology) discovery and development project portfolio, which includes small molecules, RNA therapeutics, gene therapy, across the neuroscience, ophthalmology, and immunology therapeutic areas.   Working in a collaborative team environment, the Senior/Principal Scientist leads the safety assessment of Genentech therapeutics by creating a best-evidence synthesis of existing knowledge and comprehensive investigations of toxicologic activity, strategic planning, and designing/implementing/supervising toxicology studies in support of program advancement. 

Responsibilities include:

• Interdisciplinary project team membership
• scientific leadership in the design and implementation of safety assessment strategies to support program advancement and decision-making
• preparation and review of regulatory documentation
• study reports and manuscripts
• representation of Genentech in meetings with regulatory authorities
• investigations into mechanisms of toxicity
• proactive management of potential safety liabilities and communication of impact to teams and governance committees.
• Experience with cross-functional teams and capability to build productive cross-functional internal and external collaborations are desired.
• Additional responsibilities include mentoring of toxicologists and as needed, team members, and lead or provide support to inter- and intra-departmental initiatives.

Qualifications:

• A PhD and post-doctorate or equivalent experience in toxicology or a relevant field along with a minimum of 5 years relevant experience in the pharmaceutical/biotechnology/CRO industry related to toxicology.
• Experience in drug development and interaction with global regulatory authorities are required.
• Experience in new modalities such as oligonucleotides and/or gene therapy is highly desirable.
• Evidence of a consistent and extensive record of impact internally and externally. 
• Board certification in toxicology is desirable.
• The successful candidate must also demonstrate strong decision-making, complex problem solving, critical data analysis and interpretation, excellent written and verbal communication skills; and the ability to build productive cross-functional collaborations both within and external to Genentech

Who we are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Unless entitled to a reasonable accommodation under applicable law, employees are required to be fully vaccinated against COVID-19 in accordance with customer requirements, the company’s health and safety obligations and/or applicable law or guidelines.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

Genentech is an equal opportunity employer,  and we embrace the increasingly diverse world around us.  Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. For more information about equal employment opportunity, visit our Genentech Careers Homepage. 

Job Level: Individual contributor

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