Research Investigator, In Vivo Pharmacology/Neuroscience

Neuroscience    ·      New Haven, CT       ·      Full time

Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: bavdegalutamide (ARV-110) and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 350 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and purpose – to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It’s an exciting time to be in drug development and it’s an exciting time to be at Arvinas. But don’t just take our word for it – here’s what Arvinas employees are saying. For more information, please visit www.arvinas.com.

Position Summary

We are seeking a candidate who is passionate about advancing novel therapies for the treatment of neurodegenerative disease. This highly motivated individual will serve as the in vivo pharmacology lead for preclinical discovery projects(s). S/He will also function as the subject matter expert for translational biomarkers and will be tasked with leading the effort to develop and transition biomarker assays to support clinical studies.

This position reports to the Senior Director, Neuroscience and will be located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• Function as in vivo pharmacology lead on neuroscience discovery projects and work cross-functionally to develop and implement preclinical study plans and strategies
• Develop assays to measure target engagement and pathway engagement in preclinical models and provide data to drive structure-activity evaluation and guide lead identification, optimization & development.
• Serve as a subject matter expert for translational science and lead efforts to develop and validate clinical biomarker assays
• Liaise with internal/external experts, and CROs to establish collaborations and projects to execute biomarker studies and identify and implement new biomarker assay platforms/technologies
• Educate, support, mentor, and grow scientists, in either a supervisory or matrix leadership capacity
• Demonstrate excellent oral and written communication skills to facilitate internal decision making and communication and to support regulatory filing and external presentations

Qualifications

• Proficiency in lab techniques and principles of in vivo pharmacology, including familiarity with histologic assessment and CNS neuroanatomy.
• Solid understanding of neurodegeneration and/or neuroscience
• Experience in assay development/validation and knowledge of various biomarker assay platforms (e.g. ELISAs, MSD, SIMOA, IHC, capillary immunoassays)
• Ability to work and problem-solve independently and to effectively prioritize efforts, manage time, and balance work between bench and desk
• Demonstrated sustained performance and accomplishment, including publications in top tier journals

Education

• Ph.D. in neuroscience, cellular and molecular biology, or pharmacology with a minimum of 5-8 years related experience; may include post-doctoral experience. Focus on drug discovery preferred.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity employer

Please click here to apply.