Scientist – Theory Group

Initiatives  –  Quantitative Cell Science   ·      San Francisco, California      ·       Full time

The Chan Zuckerberg Biohub (https://www.czbiohub.org) is a one-of-a-kind independent nonprofit research institute that brings together three powerhouse universities – Stanford, UC Berkeley, and UC San Francisco – into a single collaborative technology and discovery engine. CZ Biohub itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to make breakthroughs in medicine and develop new technologies, frequently in collaboration with our partner universities. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at CZ Biohub facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an inclusive organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

The Theory Group at the Chan Zuckerberg Biohub seeks to deepen our knowledge and control of biological processes, structure and function through understanding the physical properties of cellular and sub-cellular systems. At the Biohub, computation, mathematics and physics are being brought to bear on the complex architectures and dynamics of molecular ensembles, organelles, cells, tissues and cell populations.  Research areas include: physical models of cellular organelles (architecture, activity & interactions); modeling of cytoskeletal and organelle networks in the cell; models of molecular ensembles, protein action and function, protein-protein correlations and localization; stochastic models of dynamics and pattern formation in biological matter; statistical mechanics of cell states and populations; dynamics and selection of cell populations and lineages during development, tumor growth and evolution.

We are looking for versatile, computationally minded Scientists, with proven experience in quantitative approaches to biological problems, who thrive in an open and collaborative environment.  Research directions can include any of those listed above or could be new directions aimed at confronting and tackling the complexity of human cells.

You will

• Analyze experimental data, developing physical models and theories, draw conclusions and author papers and presentations.
• Will develop new or strengthen collaborations with colleagues
• Will produce publications in high-quality journals, internal and external presentations

You have

Essential –

• PhD in applied math, biomathematics, biophysics, or computational/theoretical physics
• 2 years minimum of postdoctoral experience in same areas
• Proficiency in computational methods and software
• Proficiency in statistical methods, data and/or image analysis

Nice to have –

• Experience with single-cell sequence data
• Versatility in analytical skills, computational mindset, good scientific writing

Chan Zuckerberg Biohub requires all employees, contractors, and interns, regardless of work location or type of role, to provide proof of full COVID-19 vaccination, including a booster vaccine dose, if eligible, by their start date. Those who are unable to get vaccinated or obtain a booster dose because of a disability, or who choose not to be vaccinated due to a sincerely held religious belief, practice, or observance must have an approved exception prior to their start date.

Examples of CZ Biohub publications and projects relevant to this posting: (not comprehensive)

• The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans – https://www.science.org/stoken/author-tokens/ST-495/full
• Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children – https://pubmed.ncbi.nlm.nih.gov/35803954/
• OpenCell: Endogenous tagging for the cartography of human cellular organization – https://www.science.org/doi/10.1126/science.abi6983
• Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature. 2022 Mar;603(7900):309-314. doi: 10.1038/s41586-022-04461-2. Epub 2022 Mar 2.
• Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly. Science. 2022 Mar 4;375(6584):eabk2432. doi: 10.1126/science.abk2432. Epub 2022 Mar 4.
• CZID: Metagenomic analysis –  https://czid.org
• NAPARI – https://napari.org/stable/
• Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq – https://www.biorxiv.org/content/10.1101/2022.07.15.500120v1
• DaXi-high-resolution, large imaging volume and multi-view single-objective light-sheet microscopy – Nat Methods. 2022 Apr;19(4):461-469. doi: 10.1038/s41592-022-01417-2. Epub 2022 Mar 21.

What We Provide

• Resources to disrupt and innovate at the frontiers of our knowledge of biology and disease
• A collegial and collaborative environment consisting of diverse expertise
• Existing collaborations within CZ Biohub: Technology Platforms (Bioengineering, Computational Microscopy, Data Science, Genomic Sequencing, Mass Spectrometry/Proteomics), Infectious Disease, and Quantitative Cell Science
• Access to collaborators, resources and facilities at our three partner universities (Stanford, UC Berkeley, and UC San Francisco) and at partner organizations in the Bay Area and beyond
• Competitive compensation and benefits commensurate with the experience

Benefits

We offer a robust benefits program that enables the important work Biohubbers do everyday. Our benefits include healthcare coverage, life and disability insurance, commuter subsidies, family planning services with fertility care, childcare stipend, 401(k) match, flexible time off and a generous parental leave policy. In addition, we honor our commitment to career development and our value of scholarly excellence through regular onsite opportunities to learn from the world’s leading scientists.

CZ Biohub is an equal opportunity employer committed to diversity of thought, ideas and perspectives. We are committed to cultivating an inclusive organization where all Biohubbers feel inspired and know their work makes an important contribution. Therefore, we provide employment opportunities without regard to age, race, color, ancestry, national origin, religion, disability, sex, gender identity or expression, sexual orientation, or any other protected status in accordance with applicable law.

Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.

Headhunters and recruitment agencies may not submit resumes/CVs through this Web site or directly to managers. CZ Biohub does not accept unsolicited headhunter and agency resumes. CZ Biohub will not pay fees to any third-party agency or company that does not have a signed agreement with CZ Biohub.

Please click here to apply.