Associate/Senior Associate/Principal Associate, Immunology Discovery

Research Biology       ·         Shanghai, China        ·         Full time

The Position

Primary Purpose of Job

• Collaborate with scientists and associates to support new drug discovery of immunology/oncology under minimal supervision by a PhD scientist.
• Perform laboratory work, including but not limited to, assessing new drug target biology, screening and characterization of small molecule compounds for on-target and off-target effects, utilizing cell-free and cell based in vitro assays including using primary human immune cells.
• Work with supervising scientist to design experiments, write experimental protocols, independently execute research plans, analyze all data, and report experimental data with high precision and accuracy.
• Record experimental protocols and data in electronic lab notebook system in English.

Principle Roles & Responsibilities / Accountabilities

• Design and execute experiments in immunology, cancer biology, cell and molecular biology using cell lines and primary human and mouse cells with minimal guidance.
• Techniques include but not limited to immune cell isolation, cellular phenotyping, cell activation and differentiation and proliferation assessment, cytokine detection, qPCR, ELISA, Western blot, cell transfection, reporter cell line generation, molecular cloning, and generate knockout and knock-in cells in vitro using genome editing techniques.
• Under minimal supervision, independently establish and optimize in vitro biochemical and cellular assays; screen and characterize compounds using cell-free and cell-based assays including but not limited to study of drug dose response, MoA, cellular efficacy, cytotoxicity, etc.
• Work within team to study PK and PD relationship and therapeutic efficacy in relevant disease models.
• Proactively solve problems and bottleneck to move research projects (and/or new technologies) forward, and may serve as point of technical consultation in certain experimental techniques and/or operation of complex instruments.
• Other related duties as required, including but not limited to purchasing reagents and consumables, organizing and maintaining laboratory records, and ensuring laboratory safety.
• Occasionally, may need to work in a flexible schedule to meet project milestones and timelines.
• Prepare standard operational protocols and study reports in English.
• With supervising PhD scientist, interpret results and present to manager and team members, and give presentations at team meetings in English.

Qualification and Experience

Education/Qualifications

• S. in immunology, cell and molecular biology, pharmacology or biochemistry

Job Required Competencies

• Proficient in planning and conducting immunology/oncology and pharmacology experiments.
• Have significant level of scientific and technical expertise and experience in cell culture, flow cytometry, cellular and molecular immunology assays, epithelial and cancer biology, and pharmacology study of compounds.
• Preferably having worked in pharma, biotech or CRO for 2-3 years or longer.
• Experience working with primary immune cells is strongly encouraged.
• Experience working with cancer cells of the gut is a plus.
• Experience in imaging e.g., confocal microscopy and imaging analysis is a plus.
• Some experience in molecular biology, molecular cloning and genome editing experience is preferred.
• Ensure lab record and data accuracy and laboratory safety.
• Preparing/presenting results in team meeting in English, help scientist prepare internal documentations or presentations.
• Independent problem solving, collaboration and teamwork are required.
• Contribute to patents and publications.
• Familiar with scientific or technical literature within the scientific field and related areas.
• Able to record and present results in English.
• Title of positions (Research Associate, Senior or Principal Research Associate) matched with candidate’s qualifications and years of experience.

Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote.  If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

Job Facts

Job Sub Category: Research Biology
Schedule: Full time
Job Type: Regular
Posted Date: Jul 11th 2022
Job ID: 202207-126939

Beginning September 30, 2021, Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date.  This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote.  If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation. 

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