Research Scientist II, Genome Engineering Molecular Biology

Research & Development      ·        Shanghai, Shanghai, China          ·      Full time

Job ID: 355690BR

Job Title: Research Scientist II, Genome Engineering Molecular Biology

Job Description

4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 21 years of Novartis–San Diego history!

The Genome Editor Protein Engineering group, a key component of the NIBR-San Diego Genome Engineering Platform, is seeking a highly motivated Research Scientist with molecular biology and tissue culture skills. This is a great opportunity to join a group dedicated to discovering and engineering the next generation of cell therapies, and a global organization committed to bringing innovative medicines to patients. The San Diego Genome Engineering Platform comprises a core team of 20+ scientists with access to a wide repertoire of world-class collaborative functions including automation, protein expression, protein engineering, molecular biology, data science, pharmacology, and drug discovery.

The successful candidate will contribute from the bench and work with the larger team to build and characterize the efficiency and on-/off-target profiles of novel genome modifying effectors tailored for key therapeutic indications.

Your Responsibilities Include, But Are Not Limited To:

• Performing molecular cloning to generate plasmid constructs with novel genome modifying effectors using techniques including PCR, Gibson assembly, DNA purification and sequence validation
• Executing cell-based assays to characterize the activity of novel genome modifying effectors in a high-throughput format
• Maintaining, culturing, cryo-preservation, etc. of mammalian cell lines
• Contribute to the analysis of results and suggest new experiments
• Communicate and work effectively with diverse project teams to accomplish shared project goals
• Maintain organized, detailed, and accurate documentation of experiments

This position will be located at the San Diego, CA site and will not have the ability to be located remotely. This position will not require any travel as defined by the business (domestic and/ or international).

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum requirements

WHAT YOU’LL BRING TO THE ROLE:

• BS/MS degree in biology, biochemistry, molecular biology, or related discipline with 3+ years of academic or industry laboratory experience
• Hands-on experience in molecular cloning techniques for the generation of plasmid constructs and use of standard DNA software (e.g. Lasergene, Snapgene, Vector NTI, Geneious)
• Hands-on experience in tissue culture and aseptic technique
• Attention to detail, ability to work independently and communicate effectively, and an eagerness to learn new things

DESIRABLE:

• Working knowledge of CRISPR/Cas, TALE, ZF, or other genome targeting and modification technologies
• Experience with transfection/electroporation/transduction of mammalian cells
• Proficiency in sample preparation for next-generation DNA/RNA sequencing, including gDNA/RNA extraction from mammalian cells
• Ability to analyze and visualize experimental data using Microsoft Excel, GraphPad Prism, Spotfire, etc.
• Experience with Python and R

Why Novartis?

766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.
We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what’s possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com or call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network (https://talentnetwork.novartis.com/network).

Division: NIBR
Business Unit: BIOLOGICS NIBR
Country: USA
Work Location: San Diego, CA
Company/Legal Entity: NIBRI
Functional Area: Research & Development
Job Type: Full Time
Employment Type: Regular
Shift Work: No
Early Talent: Yes

Please click here to apply.