Associate Scientist/Scientist, Gene Therapy Research

 San Diego, CA    ·    Full-time

Remote Type: On-Site
Location/s: US CA San Diego
Time Type: Full time
Job Requisition ID: R3706

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose – to relieve suffering for people with great needs, but few options.

What We Do:

Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson’s disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie

About the Role:

Design, develop and conduct research for validating AAV gene therapy candidates for clinical use. Execute experiments and support the validation of novel drug targets via multiple mechanisms. Conducts essential experiments to help determine and characterize mechanism of action (MoA). Analyze and present data to lead scientists in an organized and timely manner. Work will be conducted in a highly collaborative manner to advance the programs through early stages of gene therapy drug discovery and development, including existing programs and the proposal of novel projects.

Your Contributions (include, but are not limited to):

• Contribute to the design and validation of gene therapy approaches for proof-of-concept studies that will lead to IND-enabled research
• Work cross-functionally with gene therapy research and development team to achieve projects goals
• Contribute to the evaluation of emerging molecular biological or biochemical methods
• Work with the team to initiate and support new platforms, instrumentation, and technologies for gene therapies
• Phenotype animal behaviors and conduct histology to evaluate the efficacy of gene therapies
• Optimize specialized assays such as immunohistochemistry, immunofluorescence, in situ hybridization and multi-plex using automated instruments
• Analyze histological staining results using qualitative and quantitative methods with particular expertise in neuroanatomy
• Identifies and resolves technical problems through scientific understanding, options assessment, and application of innovative solutions
• Prepares clear and concise technical reports and participates in project team discussions
• Contributes to the decision-making processes within the project team by actively engaging in scientific and technical discussions
• Executes strategy, vision, and direction set by line management
• Performs other duties as assigned

Requirements:

• BS/MS in neurobiology, molecular biology, cell biology, or other relevant discipline and 4+ years of laboratory work experience in academia or industry OR
• Ph.D. in a relevant discipline and some similar experience as noted above
• Expertise in handling rodents, administering compounds (IV, PO, IP, SC), organ and blood collection, and dissecting tissues during animal necropsies
• Knowledge of cell and tissue-based histology, including in situ hybridization, immunohistochemistry, fluorescence applications, microscopy, and image analysis/processing
• Experience with a wide array of molecular biology and biochemical techniques, including nucleic acid extraction, q-PCR, dPCR, Western blotting, and ELISA
• Thorough computer literacy (Word, Excel, Graph Pad Prism, and PowerPoint)
• Experience with rodent surgeries including intracerebral and/or intrathecal injection is preferred
• Experience with animal behavioral phenotyping is desirable
• Experience with cell culture and in vitro techniques is a plus
• A proven ability to be highly productive and successful in an intense work environment with meticulous attention to detail
• A great team player
• Strong ability to multi-task and work productively in a fast-paced, highly collaborative, and diverse team environment
• Ability to follow novel scientific or technological developments, and to implement them in the laboratory
• A desire to learn new lab techniques
• Excellent written and oral communication skills
• Strong organizational and interpersonal skills
• Strong knowledge of one scientific discipline
• Good knowledge of scientific principles, methods ,and techniques
• Good knowledge and demonstrated ability to work with a variety of laboratory equipment/tools
• Good project management skills
• Good problem-solving, and analytical thinking skills
• Ability to meet deadlines

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​Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.

The annual base salary we reasonably expect to pay is $84,100.00-$134,700.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Please click here to apply.