Senior / Principal Associate Scientist – DMPK

Research & Development           ·        Cambridge, MA        ·         Full time 

• Cambridge, MA
• Full-time
• Department: Research & Development
• Region: US

Job Description

About This Role  

Biogen’s Drug Metabolism and Pharmacokinetics (DMPK) department is seeking a highly motivated Principal Associate Scientist with excellent knowledge and hands-on experience in conducting large molecule bioanalysis to enable discovery and development of innovative therapeutics for people living with serious neurological and neurodegenerative diseases. This role is part of a dynamic and friendly team with functions of bioanalysis and biodistribution of new modalities including antibody and gene therapy drug candidates as well as in vivo PK.

What You’ll Do

• Develop and conduct ligand binding assays (LBA) and/or qPCR assays on large molecule biotherapeutics for non-clinical and possible clinical studies across Biogen’s pipelines.
• Provide high quality bioanalytical support with a focus on quantifications of large molecules such as monoclonal antibodies, fusion proteins and gene therapy medicinal products (GTMP).
• Deliver and present the experimental results to cross-functional and DMPK teams.
• Provide scientific monitoring and guidance on outsourcing studies for the method transfer, development, troubleshooting, qualification, validation and report.
• Write and review bioanalytical study protocols and reports that are suitable for inclusion in registration dossiers (IB, IND/IMPD, BLA).
• Additional opportunities can be provided such as evaluating emerging technologies, and contributing to scientific publications.

Who You Are

The primary responsibility of this bioanalytical scientist role is to perform large molecule bioanalysis on various modalities such as monoclonal antibodies, fusion proteins and GTMP. You love learning new technological skills, working through collaboration, and benefiting department and programs across the portfolio.

Why Biogen?

Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.

Qualifications

Required Skills

• Bachelors with 4 – 6 years exp in Biology, Biochemistry, Pharmaceutical Sciences, or a related field.
• Masters with 2-4 years exp in Biology, Biochemistry, Pharmaceutical Sciences, or a related field.
• Extensive knowledge and hands-on experience in conducting LBA and/or qPCR on large molecule biotherapeutics for non-GLP and/or GLP studies.
• Hands-on experience with assay execution, method development, validation, and troubleshooting of LBA and/or qPCR assays.
• Excellent communication skills, be organized and attention to details.

Preferred Skills

• Experience in quantification of anti-drug antibody (ADA) or biomarkers by LBA or LC-MS.
• Experience in biodistribution, Elispot assay and RNAscope technology.

Additional Information

All your information will be kept confidential according to EEO guidelines.

Please click here to apply.