Who We Are

The OMNI-Biomarker Development department at Genentech provides translational science support to inform the clinical development of novel personalized therapeutics in disease areas of Ophthalmology, Metabolism, Neuroscience, Immunology and Infectious Diseases (OMNI). Our biomarker strategies are designed to study the molecular pathways driving disease and to establish the mechanism of action of our therapeutics. We focus on prognostic, predictive and pharmacodynamic biomarkers to enable our vision of “the right drug for the right patient at the right dose.”

The Position

We are seeking a highly motivated Principal / Senior Principal Scientist to join the OMNI-Biomarker Development Department at Genentech, Inc to drive our biomarker and drug development efforts in fibrosis. Our department is responsible for defining biomarker and personalized healthcare strategies in our clinical trials, and interpreting biomarker results to support biological rationale and decision making. Through our clinical trials, as well as our forward and reverse translation efforts, our group identifies and implements biomarkers to evaluate disease heterogeneity, target-engagement, mechanism of action, and disease modification. Biomarker team leaders within the department provide scientific leadership for biomarkers in clinical trials ranging from early proof-of-concept through marketed products as well as observational cohorts.

Responsibilities:

The successful candidate will join our dynamic team and work to identify biomarkers in support of drug development projects in fibrotic indications including IPF, Systemic Sclerosis and Chronic Kidney Disease.  The candidate will support clinical trials, lead efforts for data generation and analyses within internal studies, and participate in external academic collaborations relating to understanding biomarkers in fibrosis. The successful Senior/ Principal Scientist will have the opportunity to grow into a project biomarker team leader. Success in these responsibilities requires a thorough understanding of disease and drug target biology, creativity and attention to detail, and experience in integrating biomarkers into clinical trials.

Candidates familiar with molecular/immunological techniques and analytical methods including immunoassay, qPCR, genetics, functional genomics, scRNA sequencing, cellular immunology, or analytics (knowledge of R or other data analysis programming experience) are preferred.

The position requires working in close partnership across various functions including Research, Bioanalytical Assay Science, Diagnostics, Clinical Sciences, Clinical Pharmacology, Clinical Biostatistics, Bioinformatics, Regulatory and with external partners. Effective communication is essential and includes presentations at cross-functional teams, internal review committees, and external conferences, and will also involve writing biomarker sections of clinical protocols, reports, regulatory filings and scientific publications.

Who You Are

• Candidate must have a PhD or MD in Immunology or a related field with at least 2 years of post-doctoral or fellowship experience in basic or translational research either in an academic and/or industry setting.
• Candidate must demonstrate a high level of independence and be able to develop hypotheses and direct analysis plans.
• Strong writing and communication skills are required, as evidenced by publications, meeting abstracts and/or drug development reports.
• Candidate must be passionate about using their understanding of disease biology to make impactful contributions to clinical drug development.
• Willingness to collaborate across time zones, including our Swiss site, is a must. 
• Preferred candidates will have prior experience in the study of fibrotic disease and a demonstrated ability to function as part of a cross-functional team such as research or clinical trial project teams.

The expected salary range for this position based on the primary location of California is $139,000 – $258,180.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance.  This position also qualifies for the benefits detailed at the link provided below.

Benefits

Relocation Assistance is provided for this posting.

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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.

Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote.  If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.