Research Fellow – Neuroscience

Research             ·            Jacksonville,  FL            ·           Full time

Research Fellow – Neuroscience

Job ID: 302920

Date posted: 06/13/2023

Location: Jacksonville, FL

Time Type: Full Time

Category: Research

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Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic. You’ll thrive in an environment that supports innovation, is committed to ending racism and supporting diversity, equity and inclusion, and provides the resources you need to succeed.

Responsibilities

A Postdoctoral research positions are available in the laboratory of Dr. Wolfdieter Springer to investigate pathogenic mechanisms of neurodegeneration at Mayo Clinic in Jacksonville, Florida.

The Springer lab focusses on selective autophagy pathways, in particular mitophagy, and how alterations therein contribute to aging and neurodegenerative disorders. The lab employs a multi-disciplinary approach using state-of-the-art techniques in cell biology, biochemistry, and imaging to illuminate the underlying disease biology in iPSC-derived cell and organoid models, in vivo in mice, and in human clinical and neuropathological specimens.

The Research Fellow will support ongoing research projects related to PINK1-PRKN mitophagy. 

Specific research projects include:

• Investigation of selective autophagy mechanisms in Alzheimer’s disease, Lewy body dementia, and Parkinson’s
• Biomarker development to monitor selective autophagy pathways in cells, tissues, and biofluids,
• Validation of disease signatures resulting from altered mitophagy, as well as
• Genetic and pharmacological stimulation of mitophagy during aging and neurodegeneration. Specific tasks and objectives include support of cell culture, gene-editing, and mouse and human autopsy brain tissue analyses using a variety of molecular, cellular, biochemical, and imaging techniques and the execution of informative research experiments that test a proposed hypothesis.

The individual will be trained to design experiments, set up experimental conditions as well as to analyze, graph, interpret and discuss outcomes. The individual is expected to thoroughly document the experimental conditions, goals and results and to further skills to interact and work collaboratively as part of a team of laboratory researchers. Effective written and oral communication skills are required. Continuous 360 degree evaluation will help achieve training and career goals.

• Applications are invited from highly motivated candidates holding a recent Ph.D. or M.D./Ph.D. with a strong research background in neuroscience, cell biology, or biochemistry.
• Expertise in iPSC models, mouse work, or multi-omics approaches is desirable. In addition, qualified candidates should have a record of impactful, peer-reviewed publications.
• Excellent verbal and written communication skills in English are essential.

How to Apply:

Qualified candidates should send a cover letter outlining research interests and achievements along with their curriculum vitae to Wolfdieter Springer (Springer.Wolfdieter@mayo.edu).

For an overview of research and laboratory visit: https://www.mayo.edu/research/labs/translational-cell-biology-parkinsons-disease/overview

Mayo Clinic and the Department of Neuroscience offer an outstanding research and training environment with a competitive stipend and a generous fringe benefit package.

Qualifications

• A Research Fellow position in Life Sciences (LS) will require knowledge of either clinical-based research or laboratory-based research often obtained from a postdoctoral program.

A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.

Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.

Exemption Status: Exempt
Compensation Detail: Education, experience and tenure may be considered along with internal equity when job offers are extended.
Benefits Eligible: Yes
Schedule: Full Time
Hours/Pay Period: 80
Schedule Details: Varies
Weekend Schedule: Varies
International Assignment: No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.

Affirmative Action and Equal Opportunity Employer

As an Affirmative Action and Equal Opportunity Employer Mayo Clinic is committed to creating an inclusive environment that values the diversity of its employees and does not discriminate against any employee or candidate. Women, minorities, veterans, people from the LGBTQ communities and people with disabilities are strongly encouraged to apply to join our teams. Reasonable accommodations to access job openings or to apply for a job are available.

Recruiter: Amy Hoffman
Department Title: Research

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