Scientist/Sr. Scientist – In vitro, Cell Model Development

Research and Development Group               ·                US CA San Diego (On site)            ·           Full-time

Remote type: On-Site
Locations: US CA San Diego
Time type: Full time
Job Requisition ID: R3928

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose – to relieve suffering for people with great needs, but few options.

What We Do:

Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson’s disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie

About the Role:

We are looking for a collaborative and highly motivated scientist to join our Research team. The primary role will be to support multiple projects and to provide subject matter expertise with cell engineering techniques to generate novel, physiologically relevant cell line/disease models as well as to apply cellular and molecular biology techniques to perform gene and protein expression characterization. You will also be involved in the production and support of more complex, disease relevant primary/iPSC derived cellular models when needed. This individual will be involved in the application of the developed disease models for cell-based assays. The ideal candidate must have outstanding written and verbal communication skills, computer literate and a strong work ethic, and be able to multitask and prioritize responsibilities. This candidate will be able to work together with his or her supervisor to seamlessly provide consistent support to the in vitro team by supporting multiple new target screening and lead optimization campaigns.

Key Responsibilities:

• As a scientist you will be an innovative thinker with the ability to work autonomously: design and carry out experiments and propose creative solutions to challenging problems
• Provide expertise in cell culture optimization, cell engineering/transfection techniques (Crispr/Cas9), cell culture expansion and differentiation, scale up/down and cell biology/physiology for cell model development
• Provide molecular and cell biology support to execute standard cell culture processes including transfection, selection, sub-cloning, clonal expansion, and banking as well as characterize the generated cell model
• Works in the laboratory independently within a collaborative environment with minimal guidance to explore, develop and validate novel models for neurological disorders
• Help to identify, evaluate, and, where applicable, implement novel methods or technologies that would enhance workflow efficiencies and/or improve the quality of cell model deliverables
• Develop/maintain knowledge of current literature/trends, propose novel concepts and cutting-edge techniques
• Document research and conducts work in a safe manner in accordance with company and departmental guidelines
• Other duties as assigned

Requirements

• BA/BS in Biochemistry, Biology, bioengineering or a related fields and 5+ years of Biotechnology industry experience including gene therapy-specific techniques and cell model development with emphasis in Neuroscience
• MS degree in relevant discipline and 3+ years as noted above
• PhD and some industry experience noted above
• Hands-on experience developing cell model for neurological/other diseases, using different immortalized cell lines, neuroblastoma and/or iPSC culture and cell clone characterization methods
• Demonstrated tissue culture experience, including knowledge of stem cells/iPCS, neural precursor cell handling and differentiation into different neuronal types
• Prior hands-on experience in biochemistry techniques including (but not limited to) qPCR, western blot, immunoassays, FACs analysis, protein assay development and data analysis
• Strong knowledge in developing new biochemical and cell-based/potency assays is a plus
• Working experience using modern automation, LIMS, data analysis and informatics systems is a plus
• Demonstrated ability to multi-task and be highly productive in a multidisciplinary, fast-paced and diverse environment
• Ability to work as part of a team; may train lower levels
• Strong communications, problem-solving, analytical thinking skills

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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.

The annual base salary we reasonably expect to pay is $103,200.00-$149,700.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Please click here to apply.