Research Technician II – Neuroscience

Houston, TX            ·           Full time

Title:  Research Technician II – Neuroscience

• Division:  Neuroscience
• Schedule:  Monday – Friday; 8:00 am – 5:00 pm
• Work Location:  Houston, TX
• Salary Range:  $28,710 – $38,830
• FLSA Status:  Nonexempt
• Requisition ID:  16777

Summary

The Jiang lab at Baylor College of Medicine and Neurological Res Inst at Texas Children´s Hospital is looking for a full-time lab technician. The Jiang laboratory in the Departments of Neuroscience at Baylor College of Medicine is to use a multi-disciplinary approach, includes single-cell transcriptomics, Patch-seq, multi-patch clamp recording, machine learning, and complicated genetic tools to understand cellular heterogeneity and circuit organization of healthy and diseased brains. The lab uses rodent and primate models, that includes surgically resected human tissue, to understand brain cell types with the molecular, spatial, and morpho-electric annotations, and how genetic lesions (related to epilepsy and autism) give rise to culprit cell types that contribute to the core symptoms of the diseases. The technician can learn more about the research at https://www.bcm.edu/research/labs/xiaolong-jiang, or from recent publications in the lab:

• Jiang X., Shen S., Cadwell C.R., Berens P., Sinz F., Ecker A.S., Tolias A.S. (2015). Principles of Connectivity among Morphologically Defined Cell Types in Adult Neocortex. Science. Vol. 350 no. 6264 DOI: 10.1126 
• Cadwell CR, Palasantza A, Jiang X, Berens P, Deng Q, Yilmaz M, Reimer J, Shen S, Bethge M, Tolias KF, Sandberg R & Tolias AS (2016). Morphological, electrophysiological, and transcriptomic profiling of single neurons using Patch-seq. Nature Biotechnology, 34(2), 199-203. doi: 10.1038/nbt.3445. Epub 2015 Dec 21. 
• Scala F, Kobak D, Shan S, Bernaerts Y, Laturnus S, Cadwell CR, Hartmanis H, Castro J, Tan ZH, Sandberg S, Berens P, Jiang X*, Tolias AT*. Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas. Nature Communication. volume 10, Article number: 4174 (2019) *co-corresponding authors
• McKinney A, Hu M, Hoskins A, Mohammadyar A, Naeem N, Jing J, Patel S, Sheth RB. Jiang X. Cellular composition and circuit organization of the locus coeruleus in adult mice. Elife. 2023 Feb 3;12:e80100.
• Shen S, Scala F, Reimer J, Fu J, Fahey P, Sinz. F, Jiang X#, Tolias AS. Distinct organization of two cortico-cortical feedback pathways. Nature Communication, 2022 Oct 27;13(1):6389. #*co-corresponding authors
• Jing J, Hu M, Ngodup T, Ma Q, Lau, SNN, Ljungberg C, McGinley MJ, Trussell LO, Jiang X. (2023). Comprehensively Defining Cellular Specializations for Initiating Parallel Auditory Pathways in the Mouse Cochlear Nucleus. bioRxiv. https://www.biorxiv.org/content/10.1101/2023.05.15 

Job Duties

• Maintains mouse colonies, genotyping, PCR.
• Prepares for single-cell RNA-sequencing.
• Performs basic immunostaining and other histological staining.
• Performs neuronal reconstruction with Neurolucida.
• Collects, compiles, and analyzes data.
• Documents results of experiments.
• Assists Principal Investigator and postdocs in related projects.

Minimum Qualifications

• Bachelor’s degree in a Basic Science or related field. Four years of related experience may substitute for degree requirement.
• No experience required.

Preferred Qualifications

• Master’s degree in basic science.
• Experience for more than one year is a plus.

Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

Please click here to apply.