JOB SUMMARY

The In Vivo Enteric Nervous System/Neuroscience Research Associate will be a key member of the team charged with developing, qualifying, and executing in vivo assays in rodents. Specifically, the Research Associate will be part of a team attempting to uncover local gut and gut-brain circuits with the ultimate purpose of translating novel biology to treat disease.  Successful candidates must be able to work effectively both in a collaborative setting and independently while possessing outstanding written, and oral communication skills.

KEY RESPONSIBILITIES

• Viral transduction of neuronal populations within the brain, gut, and peripheral ganglia that innervate the GI tract.
• Development and validation of specific assays for more detailed characterization of gut-derived biology; i.e. motility, secretion, metabolism, inflammation
• Single cell and single nucleus sequencing of neuronal populations
• Assessing CRO capabilities and designing/monitoring/interpreting assays at CROs
• Execution of in vivo rodent pharmacokinetic/pharmacodynamic (PK/PD) studies including formulation of dosing solutions, dosing, PK/PD sampling, and necropsy
• Compilation of results into comprehensive reports

QUALIFICATIONS AND EDUCATION REQUIREMENTS

You must have:

• M.S. degree in a biological science, or B.S. degree with equivalent experience
• At least two years of hands-on research experience
• Commitment to detail for in vivo study design, execution, and data organization
• Experience with mouse experimental models

Additional preferred experience includes:

• Experience with rodent neuroscience and/or gut biology
• Exposure to rodent surgical procedures (or surgical experience)
• in vitro assay experience, either cell lines or primary culture
• Drafting animal protocols and amendments for IACUC review
• Histology experience (immunofluorescence and in situ hybridization if possible)
• Working with genetically modified animals, including behavioral phenotyping of rodents after optogenetic and/or chemogenetic manipulation

Please click here to apply.