Sr. Scientist, Discovery Biology

CA San Diego  · Fulltime

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose – to relieve patient suffering and enhance lives.

What We Do:

Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with 28 years of experience discovering and developing life-changing treatments for people with serious, challenging and under-addressed neurological, endocrine and psychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson’s disease, endometriosis* and uterine fibroids*, with three pivotal and five mid-stage clinical programs in multiple therapeutic areas. Headquartered in San Diego, Neurocrine Biosciences specializes in targeting and interrupting disease-causing mechanisms involving the interconnected pathways of the nervous and endocrine systems. (*in collaboration with AbbVie)

About the Role:

Design, plan, and support the validation of novel drug targets via multiple mechanisms. Develop and implement relevant biochemical & cell-based assays to support identification, optimization, and characterization of novel drug candidates. Design and conduct essential experiments to characterize MoA. Analyze and present data to lead scientists and/or Discovery Biology leadership in an organized and timely manner. Work within and support biology needs of drug discovery teams.

Your Contributions (include, but are not limited to):

• Designs and performs experiments to support scientific activities and project goals involving cell and biochemical assays
• Recommends alternatives, researches new methods and techniques and may proactively seek out senior personnel and outside experts to discuss potential solutions to problems
• Generates and works with complex bioinformatic data sets, with a strong understanding of advanced data analysis and statistical tests
• Designs and generates high content imaging-based phenotypic screening data sets for novel target ID
• Responsible for advanced cell based assay development, including primary cells, tissues and iPS cells
• Maintains and updates SOPs and writes data summaries for experiments conducted.
• Handles and doses animals in a laboratory setting.
• Reviews, comprehends and complies with all SOPs, and safety and quality assurance standards at all times.
• Provides training and/or supervision to junior staff, as needed.
• Other duties as assigned.

Requirements:

• BS/BA degree and 5+ years of relevant experience, OR
• MS/MA degree and 3+ years of relevant experience, OR
• PhD or equivalent and some relevant experience (may include postdoc experience)
• Advanced tissue culture techniques, including knowledge of iPSC technology, cell handling and differentiation
• Working knowledge of phenotypic screening technologies, their implementation, and data analysis & relevant statistical tests
• Gene manipulation techniques, including cloning, and use of gene expression manipulation technologies (siRNA, miRNA, AAV transduction and CRISPR/Cas9)
• Tissue handling techniques for detection of gene and protein expression, including fixation, sectioning, IHC, histological staining, ISH
• Demonstrates solid level of understanding project / group goals and methods
• Consistently recognizes anomalous and inconsistent results and interprets experimental outcomes
• Able to explain the process behind the data and implications of the results
• Strong knowledge of one or more scientific disciplines, becoming expert in one discipline.
• Strong knowledge of scientific principles, methods and techniques.
• Strong knowledge and demonstrated ability working with a variety of laboratory equipment/tools.
• Ability to work as part of a team; may train lower levels.
• Excellent computer skills
• Strong communications, problem-solving, analytical thinking skills.
• Detail oriented yet can see broader picture of scientific impact on team.
• Ability to meet multiple deadlines, with a high degree of accuracy and efficiency.
• Strong project management skills.

Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

Please click here to apply.