Senior/Principal Scientist, DMPK

Research & Early Development    ·   San Francisco, CA   ·   Full time

The Position

We are seeking an exceptional individual for a Senior/Principal Scientist position in the Drug Metabolism and Pharmacokinetics (DMPK) department at Genentech. This leader will work with our established team support to apply physiologically based pharmacokinetic (PBPK) modeling and provide guidance to projects across our diverse portfolio that includes oncology, cancer immunology, neuroscience, immunology, and infectious disease targets. This individual would lead, provide direction and help build scientific strategy on various aspects of PBPK which our discovery and development projects will benefit from. Meanwhile, the individual will also be expected to lead the DMPK project strategy, design and execute non-clinical studies in a highly collaborative environment.

Required Qualifications:

• Opportunity of being DMPK team lead for discovery and development projects
• Represent GNE PBPK in Pharma scientific forum
• A PhD degree specializing in pharmacokinetics and/or drug metabolism or other relevant fields.
• 5+ years of previous DMPK related experience for the Scientist level. 8+ years for Senior Scientist level.
• Hands-on experience in PBPK modeling (eg. Simcyp, Gastroplus or customized models).
• Opportunity to work with various project teams from drug discovery to drug development to filing
• A strong understanding of PK and ADME concepts, and practical experience in in vitro and in vivo extrapolation in at least one of the following areas: absorption, distribution, enzyme metabolism, transporter and excretion.

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Desired Qualifications:

• Good organizational, collaboration, communication skills and flexibility are important assets.
• Familiarity with PK/PD basic methodology and relevant modeling and simulation tools (e.g. WinNonlin, ADAPT, SAAMII ).

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world’s most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

The next step is yours. To apply today, click on the “Apply for this job” button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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