Senior Scientist, Molecular Profiling- Department of Cellular and Tissue Genomics

Pharmaceuticals    ·    San Francisco, CA   ·   Full time

The Position

The Department of Cellular and Tissue Genomics within Genentech Research and Early Development is seeking a highly talented, creative and driven Senior Scientist to generate foundational atlases of tissues and blood for biological and drug discovery and to develop novel technologies for enhanced single cell genomics for tissue studies.

This individual will lead an independent research group whose mission is to develop and apply scalable tools for generating atlases of healthy and disease tissues. The scope of these activities will span biological disciplines, including immunology, molecular oncology, cancer immunology and neuroscience medicine. The scientists will play a key role in leading and contributing to teams in disease areas of focus. They will apply these tools to identify novel therapeutic targets and next-generation biomarkers to enable precision medicine therapies for patients.

Responsibilities

• Profile clinical trial samples (e.g. tissues, blood) to inform screen design and biomarker and drug discovery
• Pursue scalable tools enabling single cell genomics for tissue studies in biologically relevant tissues (e.g. patient samples, organoids)
• Develop new modalities and expanding the toolkit (e.g by deploying and developing new methods)
• Collaborate with disease experts across the therapeutic areas to design experiments tailored to biological discovery and new biomarkers and therapeutic targets
• Work together with machine learning teams to develop and apply models to describe molecular circuitry and identify new biomarkers and therapeutic targets
• Mentor colleagues to enable their scientific potential
• Publish in high quality scientific journals and present externally though presentations at key internal and external meetings, advisory boards, and conferences

Qualifications

• Ph.D., M.D. or Ph.D/M.D. with relevant postdoctoral experience in tumor immunology, molecular oncology or neuroscience. Expertise in cellular biology and molecular biology using single cell genomics and spatial methods
• Strong publication record of impactful discoveries that reveal novel biological pathways and/or advanced technologies to enable biological discovery
• Experience with performing large scale single cell profiling projects, collecting multimodal single-cell readouts (chromatin, RNA, protein) in various settings including tissues and blood
• Experience with inventing and deploying new single-cell methods
• Experience applying diverse CRISPR technologies (CRISPR gene editing, activation, repression) in vivo, ex vivo, and in cell lines is a plus
• Experience working with computational biologists including high throughput single cell genomics and interpretation of results
• Excellent interpersonal skills with demonstrated ability to work within a team comprised of diverse expertise
• Excellent mentoring skills across all levels
• Excellent oral and written presentation skills

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world’s most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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